個人簡介

從事軟物質生物物理領域生物大分子結構和功能研究。

學位教育

1993/9－2000/7 江西師範大學，物理學學士、光學碩士

2001/9－2004/4 中山大學，生物物理學博士

工作經歷

2000 – 2001 珠海亞力電子有限公司工程師

2004 – 2006 華南理工大學生物醫學工程系講師

2006 – 2007 University of Texas, Medical School at Houston博士後

2007 – 2009 California Nanosystem Institute, University of California, Los Angeles博士後

2009 – 2014 中國科2生物物理研究所，副研究員，項目研究員

2014 – 2021 清華大學生命科學2，研究系列教師，副研究員

2021 – 至今 0，瀟湘學者，教授

辦公室：量子樓209

Ｅmail:lingpengcheng@hunnu.edu.cn

承擔課題

1. 國家自然科學基金面上項目，31971122短尾科病毒對稱失配衣殼的高分辨率結構和功能研究，2020/01-2023/12，主持

2. 國家重點研發計劃，2016YFA0501100，高分辨率冷凍電鏡新技術新方法的發展及在結構生物學中的應用，2016/07-2021/06，課題骨幹

3. 國家自然科學基金面上項目，31570727，基於冷凍電鏡的呼腸孤病毒轉錄的分子機制研究，2016/01-2019/12，主持

4. 國家自然科學基金面上項目，31170697，呼腸孤病毒的結構和功能研究，2012/01-2015/12，主持

5. 國家自然科學基金青年基金，31000333，病毒的冷凍電鏡高分辨率三維重構研究，2011/01-2013/12，主持

6. 國家重點基礎研究發展計劃，2010CB912400，基於冷凍電子顯微鏡學的生物大分子的高時空分辨率的結構和功能研究，2010/01-2014/12，課題骨幹

代表性論文

1. Hao Xiao, Junquan Zhou, Fan Yang, Zheng Liu, Jingdong Song, Wenyuan Chen*, Hongrong Liu*, andLingpeng Cheng*. Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures,Viruses, 2023, Vol. 15, 335.

2. Zhen Han, Wanjuan Yuan, Hao Xiao, Li Wang, Junxia Zhang, Yuning Peng,Lingpeng Cheng*, Hongrong Liu*, and Li Huang*.Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail,Proceedings of the National Academy of Sciences, USA,2022, Vol. 119,e2119439119.

3. Hongrong Liu* andLingpeng Cheng*, Viral Capsid andPolymerase in Reoviridae.Subcellular Biochemistry 99, Chapter 17, Springer, 2022

4. Jing Zheng, Wenyuan Cheng, Hao Xiao, Fan Yang, Xiaowu Li, Jingdong Song, Lingpeng Cheng*, and Hongrong Liu*.A capsid structure of ralstonia solanacearum podoviridae GP4 with a triangulation number T=9,Viruses, 2022, Vol. 14, 2431.

5. Wenyuan Chen, Hao Xiao, Li Wang, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*. Structural changes in bacteriophage T7 upon receptor-induced genome ejection,Proceedings of the National Academy of Sciences, USA, Vol. 118, (2021) e2102003118.

6. Wenyuan Chen, Hao Xiao, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang, Li Wang, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation,Protein & Cell, 11 (2020): 374–379

7. Xiaowu Li, Li Wang, Xurong Wang, Wenyuan Chen, Tao Yang, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*.Structure of RdRps within a transcribing dsRNA virus provides insights into the mechanisms of RNA synthesis,Journal of Molecular Biology, 432 (2020): 358-366

8. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, andLingpeng Cheng*.Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly,Proceedings of the National Academy of Sciences, USA, 115 (2018): 7344-7349

9. Bin Zhu,Lingpeng Cheng*, Hongrong Liu*. Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopyChinese Physics B 27 (2018)

10. Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*,Lingpeng Cheng*.Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV,Journal of Molecular Biology.429 (2017): 79-87

11. Xiaowu Li, Hongrong Liu*,Lingpeng Cheng*. Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM,Biophysics Reports. 2016, 2 (1): 25-32

12. Hongrong Liu* andLingpeng Cheng*.Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus,Science, Vol. 349, (2015), pp: 1347-1350

13. Bin Zhu, Chongwen Yang, Hongrong Liu*,Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, and Ping Zhu, Identification of the active sites in the methyltransferases of a transcribing dsRNA virus,Journal of Molecular Biology,Vol. 26, (2014), pp: 2167-2174

14. Lingpeng Cheng, Xiaoxing Huang, Xiaomin Li, Wei Xiong, Wei Sun, Chongwen Yang, Kai Zhang, Ying Wang, Hongrong Liu, Xiaojun Huang, Gang Ji, Fei Sun, Congyi Zheng*, and Ping Zhu*, Cryo-EM structures of two bovine adenovirus type 3 intermediates,Virology. Vol. 450, (2014), pp: 174–181

15. Chongwen Yang, Gang Ji, Hongrong Liu, Kai Zhang, Guangqiao Liu, Fei Sun, Ping Zhu* andLingpeng Cheng*. Cryo-EM Structure of a transcribing cypovirus,Proceedings of the National Academy of Sciences, USA. Vol. 109, (2012), pp: 6118–6123

16. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji,Lingpeng Cheng*, and Hongrong Liu*. Conserved fiber-penton base interaction revealed by a nearly atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction,Journal of Virology.Vol. 86, (2012), pp:12322-12329

17. Lingpeng Cheng, Jingchen Sun, Kai Zhang, Zongjun Mou, Xiaoxing Huang, Gang Ji, Fei Sun, Jingqiang Zhang*, and Ping Zhu*,Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping.Proceedings of the National Academy of Sciences, USA. Vol. 108, (2011), pp: 1373-1378

獲獎情況

1. 2021年湖南省科學技術一等獎（冷凍電鏡三維重構算法研究與病毒原子結構解析），排名第2。

2. 2010年教育部自然科學二等獎（病毒的電子顯微學研究），排名第4。